WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

*Wafaa Mohsin Imran and Dr. Bushra J. Al. Rubayae

ABSTRACT

Background: Polycystic ovarian syndrome (PCOS) affects reproductive-aged women. This syndrome causes infertility, insulin resistance, obesity, cardiovascular disease, and other health difficulties. Lifestyle mistakes cause polygenic, polyfactorial, systemic, inflammatory, dysregulated steroid state, autoimmune illness PCOS. The aim of study is to evaluate the role of C- reactive protein / Albumin ratio as a new biomarker in diagnosis of poly cystic ovarian syndrome. Method: Babylon Maternity and Pediatric Hospital conducted a case-control research from January to December 2019. 100 women (50 case and 50 control) aged 18–37 were studied. PCOS cases. Age, marital status, parity, occupation, residence, risk factors, gynecological history, past medical history, drug history, family history, BMI, general and local examination, blood test, and ultrasound were examined. Vein puncture was used to acquire 5 ml of blood from each individual, which was placed in a flat tube and centrifuged at 2000x g for 5 minutes. Fasting glucose, insulin, CRP, Albumin, and CRP/Albumin ratio were measured in serum. Sandwich-ELISA (Elabscience/China) assessed CRP and albumin. Results: Cases had a significantly higher CRP/Albumin ratio than controls (P < 0.001). Cases had greater BMIs than controls (P 0.001). BMI highly positively correlates with CRP (P0.001). Age does not affect CRP/Albumin ratio (P=0.365). Case group CRP/Albumin ratio was negatively correlated with parity (P < 0.001). Conclusion: The study concluded that CRP /Albumin ratio significantly increase in patients with PCOS.