WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Dr. Dalya Zuhair Basheer* and Prof. Dr. Khitam Razzak Al-Khafaji

ABSTRACT

Introduction: The rise in prostate cancer (PCa) morbidity and mortality over the years has led to widespread screening and early detection, especially for high-risk groups, as well as advancements in various treatment options. PCa encompasses a range of diseases. The study’s objective is to determine the relationship between prostatic adenocarcinoma's age, Gleason score, grade, and perineural invasion. Method: Cross-sectional research of 160 male adenocarcinoma patients at Ghazi Al-Hariri teaching hospital for surgical specialties and private laboratory from January 2019 to December 2022. All patients get age, procedures, peri neural invasion, Gleason score, and grades. No exceptions. Results: 160 prostatic adenocarcinoma patients, mean age 65.6 ± 9.7 years, cross-sectional research. 37.5% of patients aged 60-69, 31.3% aged 70-79. 98.8% had prostatic biopsies. 17.5% had positive peri neural invasion.46.25% had 4+4 Gleason scores, 16.25% have 3+4, and 9.38% have 4+3 and 4+5. 48.75% of patients were grade 4, 18.75% grade 5, and 16.25% grade 2. Peri neural invasion is associated with Gleason score: 100% of patients with 5+3=8 have positive peri neural invasion, 64.7% of patients with 4+5=9 do too. All Gleason 3+3=6, 3+5=8, 5+4=9, and 5+5=10 patients exhibit negative perineural invasion. Age, procedures, and grade do not affect perineural invasion. Conclusion: our study highlights the significant association between Gleason score and Peri neural invasion in prostatic adenocarcinoma, while revealing no associations with age, biopsy procedures, or cancer grade. These findings underscore the heterogeneity and complexity of the disease, emphasizing the need for personalized assessment and treatment strategies.

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