WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Souma Edrees*, Jamal khaddam and Fawaz Baddour

ABSTRACT

Background and Objective: psoriasis is frequently considered as a multisystem disease. Many studies have shown a potential relationship between psoriasis and bone comorbidity. This study was designed to evaluate the presence of osteoporosis and osteopenia in Syrian psoriatic patients. Methods: cross sectional study of 90 patients, including 51 psoriatic patients and 39 healthy adults. Collected data included age, gender, body mass index, disease area and severity index (PASI), duration of the disease (cases group), the presence of psoriatic arthritis (case group) and dual energy X ray absorptiometry (DXA) of the left femur and lumbar area. These statistic variables were compared with the variables of 39 healthy adults. Results: of 90 samples; 51 patients with psoriasis 31(60.8%) were male and 20(39.2%) were females, 39 healthy control 21(53.8%) males and 18(46.2%) females. 9(17.6%) cases had left femur osteopenia in comparable with 4(10.3%) controls (p value 0.3). Whereas 16(31.4%) cases had osteopenia and 5(9.8%) had osteoporosis of the lumbar area, 10(25.6%) controls had osteopenia and 2(5.1%) had osteoporosis of the lumbar area (p value 0.5). Conclusion: although Patients with psoriasis did not have statistically important relationship with osteoporosis and osteopenia there was a clinically important relationship. There was a negative influence of both psoriatic arthritis and the duration of the disease on the bone mineral density. There was no influence of disease severity on the bone comorbidity. There was a high incidence of osteoporosis and osteopenia within the control group, which could be attributed on the one hand to the small sample size, and on the other hand to the poor economic and nutritional conditions that Syria has been suffering from for more than a decade, which in turn will necessarily negatively affect bone density.

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