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STUDY OF THE ROLE OF MEAN PLATELET VOLUME IN PREDICTING ABORTION
*Nour Alhaji, Ahmad Yousef, Sahar Hasan
Background: The termination of pregnancy by abortion in the first trimester of pregnancy and after the patient's suffering with the threat of abortion poses a social, psychological and economic dilemma, with the absence of a specific factor of high sensitivity and specificity useful in predicting when the threat of abortion occurs. Aim: Determination of the true value of the MPV titer as a cheap and available prognostic factor for predicting pregnancy outcome in patients with threatened abortion in the early stage of pregnancy. Materials and METHODS: This study is a prospective case-control study. The study included pregnant women attending the Department of Obstetrics and Gynecology Tishreen University Hospital TUH in Lattakia. In the period from the beginning of March 2022 until the end of February 2023? for those who have met the criteria for admission. The women in the study sample were divided into two groups as follows: 1. The first group included 45 women - The group of cases: it is a group of women who have the threatened abortion and who fulfill the conditions of admission and exclusion. 2. The second group included 35 women - The control group: a group of pregnant women with a normal pregnancy who went to hospital for the purpose of routine monitoring. Results: There were no statistically significant differences between the two groups in terms of age of the pregnant woman, gestational age, number of pregnancies, and number of abortions. The average number of platelets in the abortion group was higher than that of the control group, and it was higher in the event of a abortion compared to when it did not occur, but by statistical analysis the differences were not significant, which is consistent with slight changes in the number of platelets during the development of pregnancy. MPV and PDW were significantly higher (P<0.05) in the abortion threat group compared to normal pregnancy, and higher in women who developed a abortion compared to those who did not, The mean values of MPV in the abortion group were 10.4 ± 1.6 and in the normal pregnancy group 8.02 ± 0.8 with p-value = 0.001, while the mean values of PDW were 15.33 ± 1.1 in the abortion group and 13.6 ± 1.2 in the normal pregnancy group with p-value = 0.02. Conclusions: The rise in mean platelet volume can be used as a predictor of the risk of abortion. The value 10.2 achieves the best fit among the predictive values and is suggested as a cut-off value for predicting abortion.[Full Text Article]