News & Updation
Best Paper Awards
World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.
Best Article of current issue
Download Article : Click here
STEVENS - JOHNSON’S SYNDROME ASSOCIATED WITH LAMOTRIGINE – A CASE STUDY
B. Sathyanarayana Reddy*, Ramya N. and Amal Govind
Introduction: Steven-Johnson’s syndrome (SJS) is an immune complex mediated hypersensitivity reactions and has been linked as an adverse side effects to many drugs. Lamotrigine an FDA approved drug used as an anti-convulsive and also commonly used medication as mood stabilizer in bi-polar depression condition. Case report: we present a 62-year-old male a case of known epilepsy who developed SJS after 8 days of monotherapy with Lamotrigine. He was treated with steroids and supportive management. After one week he made eventful recovery. Discussion: Lamotrigine newer non-aromatic antiepileptic drug approved by FDA. Factors like monotherapy, post-partum, due to hormonal factors and strong association between HLA and antiepileptic drugs induces SJS/TEN. Here we are using SCORTEN (SCOR of Toxic Epidermal Necrosis) scale for knowing severity of illness for SJS/TEN. Conclusion: SJS and toxic epidermal necrolysis (TEN) are acute muco-cutaneous reactions characterized by generalized blistering, painful, lesions of bright erythema has high mortality and morbidity rate so requires careful attention as use of Lamotrigine in clinical practice.[Full Text Article]