WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

ISSN 2457-0400

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Indexing

  Indexing

  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
  • IFSIJ Measure of Journal Quality
  • Scientific Journal Impact Factor (SJIF)
  • International Scientific Indexing, UAE (ISI) (Under Process)
  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
  • Scholar Article Journal Index (SAJI)
  • International Scientific Indexing ( ISI )

Abstract

STEVENS - JOHNSON’S SYNDROME ASSOCIATED WITH LAMOTRIGINE – A CASE STUDY

B. Sathyanarayana Reddy*, Ramya N. and Amal Govind

ABSTRACT

Introduction: Steven-Johnson’s syndrome (SJS) is an immune complex mediated hypersensitivity reactions and has been linked as an adverse side effects to many drugs. Lamotrigine an FDA approved drug used as an anti-convulsive and also commonly used medication as mood stabilizer in bi-polar depression condition. Case report: we present a 62-year-old male a case of known epilepsy who developed SJS after 8 days of monotherapy with Lamotrigine. He was treated with steroids and supportive management. After one week he made eventful recovery. Discussion: Lamotrigine newer non-aromatic antiepileptic drug approved by FDA. Factors like monotherapy, post-partum, due to hormonal factors and strong association between HLA and antiepileptic drugs induces SJS/TEN. Here we are using SCORTEN (SCOR of Toxic Epidermal Necrosis) scale for knowing severity of illness for SJS/TEN. Conclusion: SJS and toxic epidermal necrolysis (TEN) are acute muco-cutaneous reactions characterized by generalized blistering, painful, lesions of bright erythema has high mortality and morbidity rate so requires careful attention as use of Lamotrigine in clinical practice.

[Full Text Article]