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World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.
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Abstract
STEVENS - JOHNSON’S SYNDROME ASSOCIATED WITH LAMOTRIGINE – A CASE STUDY
B. Sathyanarayana Reddy*, Ramya N. and Amal Govind
ABSTRACT
Introduction: Steven-Johnson’s syndrome (SJS) is an immune complex mediated hypersensitivity reactions and has been linked as an adverse side effects to many drugs. Lamotrigine an FDA approved drug used as an anti-convulsive and also commonly used medication as mood stabilizer in bi-polar depression condition. Case report: we present a 62-year-old male a case of known epilepsy who developed SJS after 8 days of monotherapy with Lamotrigine. He was treated with steroids and supportive management. After one week he made eventful recovery. Discussion: Lamotrigine newer non-aromatic antiepileptic drug approved by FDA. Factors like monotherapy, post-partum, due to hormonal factors and strong association between HLA and antiepileptic drugs induces SJS/TEN. Here we are using SCORTEN (SCOR of Toxic Epidermal Necrosis) scale for knowing severity of illness for SJS/TEN. Conclusion: SJS and toxic epidermal necrolysis (TEN) are acute muco-cutaneous reactions characterized by generalized blistering, painful, lesions of bright erythema has high mortality and morbidity rate so requires careful attention as use of Lamotrigine in clinical practice.
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