WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

*Dr. Shereen Abdulhussien Kzar, Dr. Rabab Alwan Taher and Dr. Nada Moaide Ragheb

ABSTRACT

Introduction: Prolactin (PRL) may be pituitary or extra-pituitary. Pituitary PRL secretion pulses. The pituitary releases prolactin every day. Prolactin (PRL) levels during in vitro fertilisation (ICSI) infertility therapy are being examined as a predictor of success. Method: An observational cross-sectional research analysed 69 fresh embryo transfer ICSI cycles in academic and private infertility clinics. On day 2, day 0 (oocyte pick up), and day 9, hormones were tested (oocyte retrieval). Pregnancy rate and hormones on days 0 and 9 were compared. Results: pregnancy rate 22% (n=15), mean serum PRL on day 9 post-oocyte pick up 52.55+- 23.54 in pregnant women, not significantly higher than the mean of 45.05+- 28.33 in sterile women (p-value 0.352). After controlling for baseline S. PRL estimated mean = 78.35, end line readings after 9 days were not statistically significant (p-value = 0.349). FFPRL on D0 as a screening test for pregnancy after ICSI may consistently distinguish between those who succeeded and those who failed (total area under the curve =0.667, P-value =0.5; at the cutoff point of FFPRL level=30 and above, sensitivity=0.667 and specificity=0.685). Conclusion: FF PRL on pick-up day (D0) may screen for pregnancy following ICSI. It reliably predicts pregnancy, which is helpful for physicians and patients during the anxious wait for confirmation, which is also affected by psychological variables and limiting activity.