WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

*Dr. Sally Najem Obaid and Dr. Suhaila Al-Shaikh

ABSTRACT

Background: Most benign female genital tract tumours are uterine leiomyomas. One-third of women with uterine fibroids have severe clinical symptoms that hinder everyday life. TNF-alpha is one of the most significant myometrium-associated cytokines in uterine fibroid biology, however several interleukins are implicated. Aim of the study: Evaluation of tumor necrosis factor alpha in symptomatic uterine leiomyoma. Method: one hundred women was included in this study,50 of them with uterine fibroid (38 symptomatic and 12 asymptomatic) and the other 50 control group women without ultrasonographically identified uterine fibroid. Blood samples were collected from all patients for biochemical analysis. Tumor necrosis factor alpha was measured in the sera by an immune enzymatic assay using Tumor necrosis factor alpha ELISA kit. Results: Serum tumor necrosis factor alpha level was compared between the two study groups using Student’s t-test. There was a highly significant difference between cases (3.08±0.83) pg./mL and controls (2.04±0.84) pg./mL with a mean difference of (1.04) pg./mL, P-value < 0.001. Also there's no significance difference with age, BMI and parity with P value of (0.713, 0.922, 0.051) respectively. Serum tumor necrosis factor was highly significant in patient with fibroid who present with heavy menstrual bleeding and dysmenorrhea with a P value of (0.0267, 0.038) respectively. Also it shows no significant deference in patient who present with irregular menstrual cycle (P value is 0.267), urinary symptoms (P value is 0.115) and even in asymptomatic patient. Conclusion: Uterine fibroids and elevated blood TNF-a levels were substantially correlated. TNF-a did not correlate with age or BMI. TNF-a did not correlate with fibroid location, size, MC regularity, or infertility.

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