WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Mais Kadhim Shaker* and Dr. Nadia AL-Hilli

ABSTRACT

Background: threatened miscarriage affects one in five women and associated with significant emotional distress. Uncertainty about prognosis of threatened miscarriage makes it a challenge to the healthcare professionals, various biochemical markers studied to predict the outcome of threatened miscarriage but the results were conflicting. Aim of the study: to evaluate the role of pregnancy associated plasma protein A in prediction of first trimester miscarriage in those with early pregnancy bleeding. Patients and methods: A prospective case control study carried out on 100 women, 50 of them were threatened miscarriage women (case group) and 50 were healthy pregnant women (control group). Age of participants ranged from 20-35 years, gestational age 6- 8 weeks. Venous blood samples were collected to measure pregnancy associated plasma protein A levels, comparison between these two groups done, and follow up them to 20 weeks of gestation. Results: there was no significant difference in pregnancy associated plasma protein A level observed between cases (1.075±0.2181) and controls (1.05±0.198), P-value =0.944, in addition, within the cases group, there was no significant difference in pregnancy associated plasma protein A level between cases that continued pregnancy to 20 weeks and cases ended with miscarriage (P-value 0.204). Conclusion: No significant difference in pregnancy associated plasma protein A levels between normal pregnancy and threatened miscarriage groups and even between pregnancies ended with miscarriage or continues their pregnancy within threatened miscarriage group, therefore pregnancy associated plasma protein A level cannot be recommended for predicting fetal loss in patient with first trimester bleeding.

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