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THE RELATION OF PROLACTINE HORMONE AND ZINC IN THE HYPERPROLACTINEMIC INFERTILE WOMEN IN MOSUL.
Ban Khalooq Zaki*
Background: Hyperprolactinemia is the commonest endocrine disorder of hypothalamic pituitary gland axis occurring most commonly in women but it can occur also in men. The relationship of serum level of Zn with PRL in human was a matter of controversy. Some authors found that there was no correlation between Zn and PRL in both sexes. However, the weight of evidence points to the existence of inverse relationship. Aim of the study: To examine the relationship of serum PRL and serum Zn in the control women and in hyperprolactinemic infertile women before and after treatment with dopamine agonist drug (bromocriptine). Subjects Materials and Methods Serum levels of PRL and Zn were measured in 90 women aged 18-45 years selected from the relatives and patients attending the Infertility Unit at Al-Batool Hospital in Mosul during the period of five months from March 2001 so the end of July 2001. Thirty normal fertile women were allocated as controls and 60 women who were complaining from infertility and hyperprolactinemia for more than 1 year allocated as cases group before treatment. Then those women treated by bromocriptine and followed up for 3 months and allocated as cases group after treatment. Serum PRL and Zn concentrations were estimated using MINI VIDAS instrument and Atomic Absorption Spectrophotometer respectively. Results: The serum level of PRL in cases group before treatment (38.98 ng/ml) was significantly higher than in control group (10.75 ng/ml) at (p<0.005) and the mean value of serum level of Zn in cases group before treatment (66.49 ?g/dl) was significantly lower than in controls group (97.83?g/dl) at (p<0.005). The mean values of serum level of PRL among group before treatment was (38.98 ng/ml) and among cases after treatment was (20.66 ng/ml); the difference was statistically significant (p < 0.005). On the other hand, the mean values of serum level of Zn between cases group before treatment (66.49 ?g/dl) and cases group after treatment (82.45 ?g/dl) shows that Zn increases significantly (p < 0.005). Additionally, the differences of PRL and Zn between cases after treatment and controls were statistically significant at (p<0.005). The correlation between PRL and Zn in each study group was significant in the cases group before treatment only. Conclusion: The results of this work may suggest that there is a sort of reciprocal relationship between PRL and Zn.[Full Text Article]