WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

*Maysam Hamzah Abdulwahid and Prof. Dr. Manal Kamal Rasheed

ABSTRACT

Introduction: Thyroid hormones control obligatory and facultative thermogenesis and affect cardiovascular health. Due to altered lipid metabolism and musculoskeletal system abnormalities, thyroid dysfunction increases cardiovascular risk. This study was designed to determine the relationship between irisin hormone and lipid profile parameter and body mass index in hypothyroidism patients. Method: Eighty-eight participants were studied. Forty-four were newly diagnosed with hypothyroidism over 18 years old, while forty-four were healthy volunteers (matching in age and sex). Electro-chemiluminescence immunoassay assessed blood TSH, FT4, Antithyroglobulin, and antithyroid peroxidase. ELISA measured serum irisin. Blood pressure, BMI, and homogeneous enzymatic colorimetric lipid profile were assessed. Results: The results showed significant differences between patients and control groups by increase in systolic blood pressure, diastolic blood pressure, total cholesterol, triglyceride, low density lipoprotein, thyroid stimulating hormone, anti-thyroid peroxidase, and anti-thyroglobulin with p-value (0.00, 0.00, 0.002, 0.04, 0.03, 0.00, 0.00, 0.00) respectively, and significant difference by decrease in high density lipoprotein, free thyroglobulin, and Hypothyroidism patients had lower irisin levels than controls (p=0.000). Irisin is adversely linked with total cholesterol, triglycerides, and body mass index in obese hypothyroid patients (p-value 0.02). Irisin correlated positively with Anti-TPO and negatively with Anti-TG. Irisin was positively correlated with total cholesterol and Anti-TG in control group with p-value 0.04. Conclusion: Circulating irisin and a good lipid profile may lower the risk of non-communicable diseases. In hypothyroidism patients, irisin linked adversely with BMI (irisin hormone similar to thyroid hormone action). Chronic inflammation releases fibronectin type III domain-containing 5 genes, which increases irisin and anti-thyroid peroxidase in hypothyroidism patients.

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