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Abstract
PHARMACOLOGICAL ACTIONS OF CURCUMIN IN ORAL SUBMUCOUS FIBROSIS- A REVIEW
Dr. Gazala Yasmeen and Dr. Angel Srujana Moogola*
ABSTRACT
Curcumin is a naturally occurring yellow pigment isolated from the plant curcuma longa, having wide spectrum of biological actions. It is non-toxic and has a variety of therapeutic properties including antioxidant, analgesic, anti-inflammatory, fibrinolytic, antiseptic, chemotherapeutic, antiviral, antibacterial and antifungal activity. Curcumin has been found to possess anticancer activities via its effects on variety of biological pathways involved in mutagenesis, oncogene expression, cell cycle regulation, apoptosis and metastasis. Oral cancer is sixth most common form of cancer world wide. Its incidence is particularly high in India and other Asian countries. Curcumin exhibits a big promise as therapeutic agent in pre-cancerous conditions.In gel form it is component in local drug delivery system. Curcumin conjugated nanoparticles can be used as anticancer agent. Curcumin due to its properties can be used in patients with oral submucous fibrosis, as application of it is beneficial and inexpensive too.
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