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Abstract
USING BENTONITE HYDROGEL FOR PREPARATION OF DICLOFENAC SODIUM AND IBUPROFEN SUSTAINED-RELEASE TABLETS
Rashad M. Kaoud*, Eman J. Heikal and Taha M. Hammady
ABSTRACT
Objective: In this research, bentonite (BEN) was employed to prepare sustained- release tablets of diclofenac sodium (DS) and ibuprofen (IBU) after wet and dry granulation. Methods: Granules flowability have been assessed. Also, Fourier Transform Infrared Spectroscopy (FTIR) has been used to determine the drug's compatibility with BEN. The study was conducted to determine the mechanical strength and weight uniformity of the tablets. In both acidic and recommended compendial media, the dissolution profiles were examined. The gel structure of each drug was reduced in an acidic medium, resulting in two enteric-coated tablet formulations for each drug. Results: The granules were easily flowable. Furthermore, FTIR spectra revealed no interaction between the drug and BEN. In addition, the formulated tablets met their compendial requirements. According to the data fitting, the drug is released in a fickian manner. Meanwhile, the enteric coating the tablets may preserve their sustained- release behaviour. Even without a binder, the mechanical strength and release behaviour of the tablets remained unchanged. This suggests that BEN is an effective binder on its own. Conclusion: BEN has been used successfully to formulate sustained release tablets using both wet and dry granulation methods. When exposed to acidic media, the enteric coating, on the other hand, is critical for protecting the gel structure of BEN.
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