WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
  • IFSIJ Measure of Journal Quality
  • Scientific Journal Impact Factor (SJIF)
  • International Scientific Indexing, UAE (ISI) (Under Process)
  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
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Abstract

URINARY BLADDER CARCINOMA CLINICOPATHOLOGICAL CORRELATION

*Asmaa Ahmed Marouf, MBChB and Khitam Razzaq Kadhim

ABSTRACT

Introduction: Urinary bladder neoplasia is a leading cause of death and disability across the world. In 90% of bladder cancers, urothelial carcinoma is the primary tumor. The aim of study is to characterize the clinical and pathological aspects of newly diagnosed cases of bladder cancer that were verified by histological examination. Method: Cross-sectional study of 100 bladder cancer patients. Age, gender, tumor type, grade, and bladder cancer invasion were prospectively investigated. After initial clinical examination and routine hematological, biochemical, and radiological tests, all patients received cystoscopy and transurethral excision (TURBT). None of the patients had a TURBT before hospitalization. Papillary tumors were excised from each patient. Solid muscle invasive tumors are completely excised or debunked. Cystoscopy and histopathology were compared. Data were acquired and updated at hospital discharge and urology outpatient clinic follow-up. Results: the study included 100 bladder cancer patients. Patients averaged 62.52 ±14.45 years old, and 30% were beyond 65 years (65 – 74). 85 males, 15 females. 19 cases had both papillary and squamous cell carcinomas. 70 high-grade tumors, 30 low-grade. Invasive carcinomas were discovered in 88 cases: 60 (68.2%) stromal invasive cancers, 9 (10.2%) stromal & muscle-invasive cancers, 7 (8%) stromal & lympho-vascular invasive cancers, and 12 (13.6%) stromal & muscle & lympho-vascular invasive cancers. Statistically significant associations between tumor invasion status, patient age, and tumor grade. High grade bladder cancer was more common in persons aged 75 and with squamous cell carcinoma. Conclusion: Most patients (30%) were aged (65–74) years. 85 men, 15 women. Histopathology revealed 74 papillary cell carcinomas. 70 tumors were high-grade and 30 low-grade. Other 88 patients had invasive carcinomas; 60 (68.2%) were stromal. Among 55-64-year-olds with high-grade bladder malignancies, 69 (98.6%) were invasive. High grade bladder cancer was more common in persons aged 75 years and with squamous cell carcinoma.

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