WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Academia , Scope Database , 

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Indexing

  Indexing

  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
  • IFSIJ Measure of Journal Quality
  • Scientific Journal Impact Factor (SJIF)
  • International Scientific Indexing, UAE (ISI) (Under Process)
  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
  • Scholar Article Journal Index (SAJI)
  • International Scientific Indexing ( ISI )
  • Academia
  • Scope Database

Abstract

AN UPDATE OF USE OF THERAPEUTIC TARGETING OF MACROPHAGES POLARIZATION STATUS IN THE TREATMENT OF OBESITY INDUCED INSULIN RESISTANCE, CHRONIC INFLAMMATION AND TYPE2 DIABETES MELLITUS-A NARRATIVE REVIEW

*Dr. Kulvinder Kochar Kaur, Dr. Gautam Allahbadia and Dr. Mandeep Singh

ABSTRACT

Aim: There is escalating incidence of obesity in developing along with developed countries, believed tobe a main risk for different metabolic diseases inclusive of type2 Diabetes mellitus (T2D) Non alcoholic fatty liver disease(NAFLD), atherosclerosis besides ischemic cardiovascular disease(CVD). Earlier while in an endeavour to find different medical treatments for obesity, metabolic syndrome(MetS), NAFLD we have tried to concentrate on aetiopathogenesis of obesity, with role of different cytokines, chemokines, natural killer(NK) Cells in obesity, role of macrophages polarization in hepatic and AT, skeletal muscle macrophages. Methods: Thus a narrative review was carried out using the pubmed search engine along with Google Scholar, Web of Science, Scopus, MEDLINE, Cochrane library of sciences with the MeSH Terms; chronic low grade inflammation; impaired lipid metabolism; oxidative stress; chronicinflammation; insulin resistance(IR); insulin sensitivity; insulin receptor substrate-1; JNK; IKK/ NF?B ; JAK/STATs; therapeutic interventions from 1980’s till November 2022. Results: We found a total of 1045 articles including each group out of which we selected 209 articles for this update review regarding association of macrophages polarization status with chronic inflammation and insulin resistance and targets for generation of innovative therapies for treating insulin resistance and T2D. Conclusions: Obesity- stimulated chronic low-grade inflammation might result in insulin resistance(IR), It is well acknowledged that macrophages possess a key part in the development of inflammation. Here we detail the molecular modes regarding association of M1 M2paradigm in case of macrophages polarization, low grade tissue inflammation, insulin resistance as well T2D. Furthermore, the part of macrophages in Obesity- stimulated IR is summarized as well as therapeutic drugs, recent advancements regarding targeting macrophages for the therapy of T2D is updated. Moreover role of SGLT2 Inhibitors therapeutics has shown to be beneficial regarding macrophages polarization and browning of adipocytes, besides polarized macrophagesalterations in metabolism might aid in generation of markers for these in obesity and T2D.

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