WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Academia , Scope Database , 

ISSN 2457-0400

Impact Factor  :  6.711

News & Updation

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in WJAHR coming Issue.

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • 6th International Conference on Human and Soci

    Venue:FCT Education Resource Center, Abuja- Nigeria                                        September 22-24, 2019

  • .

    6th INTERNATIONAL CONFERENCE ON EDUCATIONAL TECHNOLOGY AND CURRICULUM STUDIES(ICETC2019) 

     

    Venue: FCT Education Resource Center, Abuja-Nigeria

    September 22-24, 2019

  • WJAHR: New Impact Factor

    WJAHR Impact Factor has been Increased to 6.711 for Year 2024.

  • New Issue Published

    Its Our pleasure to inform you that, WJAHR March 2023 Issue has been Published, Kindly check it on https://www.wjahr.com/home/current_issues

  • WJAHR: MARCH ISSUE PUBLISHED

    March 2024 Issue has been successfully launched on 1 March 2024.

Best Paper Awards

World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.

Best Article of current issue

Download Article : Click here

Indexing

Abstract

AN UPDATE OF USE OF THERAPEUTIC TARGETING OF MACROPHAGES POLARIZATION STATUS IN THE TREATMENT OF OBESITY INDUCED INSULIN RESISTANCE, CHRONIC INFLAMMATION AND TYPE2 DIABETES MELLITUS-A NARRATIVE REVIEW

*Dr. Kulvinder Kochar Kaur, Dr. Gautam Allahbadia and Dr. Mandeep Singh

ABSTRACT

Aim: There is escalating incidence of obesity in developing along with developed countries, believed tobe a main risk for different metabolic diseases inclusive of type2 Diabetes mellitus (T2D) Non alcoholic fatty liver disease(NAFLD), atherosclerosis besides ischemic cardiovascular disease(CVD). Earlier while in an endeavour to find different medical treatments for obesity, metabolic syndrome(MetS), NAFLD we have tried to concentrate on aetiopathogenesis of obesity, with role of different cytokines, chemokines, natural killer(NK) Cells in obesity, role of macrophages polarization in hepatic and AT, skeletal muscle macrophages. Methods: Thus a narrative review was carried out using the pubmed search engine along with Google Scholar, Web of Science, Scopus, MEDLINE, Cochrane library of sciences with the MeSH Terms; chronic low grade inflammation; impaired lipid metabolism; oxidative stress; chronicinflammation; insulin resistance(IR); insulin sensitivity; insulin receptor substrate-1; JNK; IKK/ NF?B ; JAK/STATs; therapeutic interventions from 1980’s till November 2022. Results: We found a total of 1045 articles including each group out of which we selected 209 articles for this update review regarding association of macrophages polarization status with chronic inflammation and insulin resistance and targets for generation of innovative therapies for treating insulin resistance and T2D. Conclusions: Obesity- stimulated chronic low-grade inflammation might result in insulin resistance(IR), It is well acknowledged that macrophages possess a key part in the development of inflammation. Here we detail the molecular modes regarding association of M1 M2paradigm in case of macrophages polarization, low grade tissue inflammation, insulin resistance as well T2D. Furthermore, the part of macrophages in Obesity- stimulated IR is summarized as well as therapeutic drugs, recent advancements regarding targeting macrophages for the therapy of T2D is updated. Moreover role of SGLT2 Inhibitors therapeutics has shown to be beneficial regarding macrophages polarization and browning of adipocytes, besides polarized macrophagesalterations in metabolism might aid in generation of markers for these in obesity and T2D.

[Full Text Article] [Download Certificate]