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World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.
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INVESTIGATING THE ACTIVITY OF ETHANOL EXTRACT OF GONGRONEMA LATIFOLIUM LEAF AS IMMUNOMODULATOR IN WISTAR ALBINO RATS
Tharcitus Chilaka Onwudiwe*, Prince Chiazor Unekwe, Kingsley Chimsorom Chilaka and Chidimma Nwamaka Nzerem
Recently, immunomodulation by way of stimulation is an approach employed globally to surmount the problems posed by immunosuppressive diseases such as malnutrition, HIV/AIDS, cancer and infections caused by pathogenic microorganisms. A large proportion of the world population particularly in the Sub-Saharan Africa uses medicinal plants with immunostimulatory property to boost immunity in preference to conventional chemotherapeutic agents that are associated with high cost, adverse effects and risk of infection on prolonged use. Gongronema latifolium leaf is used in traditional medicine as an immunomodulator in South Eastern Nigeria. The aim of this study was to investigate the activity of ethanol extract of Gongronema latifolium leaf as an immunomodulator in Wistar albino rats. This was done by determining the total and differential blood cells count, neutrophil adhesion to nylon fibres, hemagglutination antibody titre and delayed-type hypersensitivity response. From the results, the ethanol extract of the plant in dose-dependent manner, significantly (p<0.05) increased the total blood cells count, neutrophil adhesion to nylon fibres, hemagglutiation antibody titre and foot pad thickness in delayed-type hypersensitivity response. These findings therefore validate the tradomedicinal claim on Gongronema latifolium as an immunomodulator.[Full Text Article]