WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

ISSN 2457-0400

Impact Factor  :  5.464

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Indexing

Abstract

INVESTIGATING THE ACTIVITY OF ETHANOL EXTRACT OF GONGRONEMA LATIFOLIUM LEAF AS IMMUNOMODULATOR IN WISTAR ALBINO RATS

Tharcitus Chilaka Onwudiwe*, Prince Chiazor Unekwe, Kingsley Chimsorom Chilaka and Chidimma Nwamaka Nzerem

ABSTRACT

Recently, immunomodulation by way of stimulation is an approach employed globally to surmount the problems posed by immunosuppressive diseases such as malnutrition, HIV/AIDS, cancer and infections caused by pathogenic microorganisms. A large proportion of the world population particularly in the Sub-Saharan Africa uses medicinal plants with immunostimulatory property to boost immunity in preference to conventional chemotherapeutic agents that are associated with high cost, adverse effects and risk of infection on prolonged use. Gongronema latifolium leaf is used in traditional medicine as an immunomodulator in South Eastern Nigeria. The aim of this study was to investigate the activity of ethanol extract of Gongronema latifolium leaf as an immunomodulator in Wistar albino rats. This was done by determining the total and differential blood cells count, neutrophil adhesion to nylon fibres, hemagglutination antibody titre and delayed-type hypersensitivity response. From the results, the ethanol extract of the plant in dose-dependent manner, significantly (p<0.05) increased the total blood cells count, neutrophil adhesion to nylon fibres, hemagglutiation antibody titre and foot pad thickness in delayed-type hypersensitivity response. These findings therefore validate the tradomedicinal claim on Gongronema latifolium as an immunomodulator.

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