WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Academia , Scope Database , 

ISSN 2457-0400

Impact Factor  :  6.711

News & Updation

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in WJAHR coming Issue.

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • 6th International Conference on Human and Soci

    Venue:FCT Education Resource Center, Abuja- Nigeria                                        September 22-24, 2019

  • .

    6th INTERNATIONAL CONFERENCE ON EDUCATIONAL TECHNOLOGY AND CURRICULUM STUDIES(ICETC2019) 

     

    Venue: FCT Education Resource Center, Abuja-Nigeria

    September 22-24, 2019

  • WJAHR: New Impact Factor

    WJAHR Impact Factor has been Increased to 6.711 for Year 2024.

  • WJAHR: DECEMBER ISSUE PUBLISHED

    DECEMBER 2024 Issue has been successfully launched on 1 DECEMBER 2024.

  • New Issue Published

    Its Our pleasure to inform you that, WJAHR December 2024 Issue has been Published, Kindly check it on https://www.wjahr.com/home/current_issues

Best Article Awards

World Journal of Advance Healthcare Research (WJAHR) is giving Best Article Award in every Issue for Best Article and Issue Certificate of Appreciation to the Authors to promote research activity of scholar.

Best Article of current issue

Download Article : Click here

Indexing

  Indexing

  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
  • IFSIJ Measure of Journal Quality
  • Scientific Journal Impact Factor (SJIF)
  • International Scientific Indexing, UAE (ISI) (Under Process)
  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
  • Scholar Article Journal Index (SAJI)
  • International Scientific Indexing ( ISI )
  • Academia
  • Scope Database

Abstract

IN VITRO AND IN VIVO STUDY OF ANTI-DERMATOPHYTIC ACTIVITY OF THYMOL, CARVACROL, EUGENOL AND MENTHOL

Imane Jabeur, Dr. Abdelilah Dassouli, Chaimae Imane Sennouni, Dr. Mounia Oukhouia, Houda Hamdani, Dr. Adnane Remmal*

ABSTRACT

The aim of this work is to test the anti-dermatophytic activity of some Major Compounds (MCs) of Essential oils (EOs) (eugenol, menthol, thymol and carvacrol) against three dermatophytes isolated from clinical cases of dermatophytosis (Trichophyton violaceum, Microsporum canis and Trichophyton mentagrophyte). The anti-dermatophytic activity of MCs was tested in vitro by using: the broth dilution method and the agar dilution method in order to determine the minimal inhibitory concentration (MIC) and the minimal fungicidal concentration (MFC). The activity was then tested in vivo by using an experimental model of induced dermatophytosis in rabbits. Carvacrol and thymol revealed an anti-dermatophytic effect against all tested with (MIC) and (MFC) values between 250 ?g/ml and 1000 ?g/ml. The sporulation of target dermatophyte species decreased with increasing concentrations of MCs. As the most effective MC, thymol has shown a great effect on the treatment of skin dermatophytosis in rabbits caused by T. violaceum and M.canis. A significant reduction of the number of colonies sampled from the infected skin was observed at 1000 ?g/ml compared to untreated control rabbits. These results demonstrated that thymol and carvacrol are potential sources of natural fungicides and could be used as an alternative to chemical anti-dermatophytic drugs.

[Full Text Article] [Download Certificate]