WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

ISSN 2457-0400

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Indexing

Abstract

PREDICTIVE VALUE OF NEUTROPHIL TO LYMPHOCYTE RATIO AND PLATELET TO LYMPHOCYTE RATIO IN DIABETIC PERIPHERAL NEUROPATHY PATIENTS TYPE 2 DIABETES

Maha Jdeed*, Arije Boubou and Tagrid Kaddar

ABSTRACT

Background: Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes mellitus (DM). Further development of DPN can lead to diabetic foot, ulcers, amputation, seriously affecting patient life quality. Therefore, searching for a reliable indicator of DPN early diagnosis is of most significance. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte (PLR) have a close relationship with cancer, cardiovascular diseases, and diabetic microvascular concurrency diseases. We aimed to investigate the relation between NLR, PLR and DPN. Methods: A total of 129 newly diagnosed type 2 diabetes mellitus (T2DM) patients were recruited, including 43 patients without complication (DM group) as well as 86 patients complicated with DPN (DPN group). Student t test, Mann- Whiney U test, or x2 test was applied to the data of the 2 groups. Results: NLR and PLR values were remarkably higher in DPN group compared to those of DM group (2,43±1,05 vs 1,31±0,19, P?0,001), (141.26± 63.36 vs 104.93± 44.89, p<0.001) consecutively. The values of glucose, urea, white blood cells count (WBC) and neutrophils count were higher in DPN group, whereas the lymphocyte count and hemoglobin of DPN group were lower than that of DM group (P?0,05). The ROC curve analysis confirmed that the optimal cut–off point, specificity, and sensitivity in diagnosing DPN by NLR and PLR were (1.69, 97.6%, 90.7%), (88.49, 80.2%, 53.5%) consecutively. Conclusion: We showed that NLR and PLR are significantly correlated with DPN, which suggested that NLR and PLR could be an independent risk factors of DPN.

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