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PREDICTIVE VALUE OF NEUTROPHIL TO LYMPHOCYTE RATIO AND PLATELET TO LYMPHOCYTE RATIO IN DIABETIC PERIPHERAL NEUROPATHY PATIENTS TYPE 2 DIABETES
Maha Jdeed*, Arije Boubou and Tagrid Kaddar
Background: Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes mellitus (DM). Further development of DPN can lead to diabetic foot, ulcers, amputation, seriously affecting patient life quality. Therefore, searching for a reliable indicator of DPN early diagnosis is of most significance. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte (PLR) have a close relationship with cancer, cardiovascular diseases, and diabetic microvascular concurrency diseases. We aimed to investigate the relation between NLR, PLR and DPN. Methods: A total of 129 newly diagnosed type 2 diabetes mellitus (T2DM) patients were recruited, including 43 patients without complication (DM group) as well as 86 patients complicated with DPN (DPN group). Student t test, Mann- Whiney U test, or x2 test was applied to the data of the 2 groups. Results: NLR and PLR values were remarkably higher in DPN group compared to those of DM group (2,43±1,05 vs 1,31±0,19, P?0,001), (141.26± 63.36 vs 104.93± 44.89, p<0.001) consecutively. The values of glucose, urea, white blood cells count (WBC) and neutrophils count were higher in DPN group, whereas the lymphocyte count and hemoglobin of DPN group were lower than that of DM group (P?0,05). The ROC curve analysis confirmed that the optimal cut–off point, specificity, and sensitivity in diagnosing DPN by NLR and PLR were (1.69, 97.6%, 90.7%), (88.49, 80.2%, 53.5%) consecutively. Conclusion: We showed that NLR and PLR are significantly correlated with DPN, which suggested that NLR and PLR could be an independent risk factors of DPN.[Full Text Article]