WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
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Indexing

Abstract

EFFECTS OF CAPYBARA OIL ON PANCREATIC REMODELING OF C57BL/6 MICE FED A HIGH FAT DIET

Kleiton Santos Neves, Gabriel S. Thiago Cavalleiro*, Fabiana Carla dos Santos Correia, Vitor Pires da Costa, Rodrigo Neto Ferreira and Jorge José de Carvalho

ABSTRACT

Considering the importance of the pancreatic role in the homeostasis of the organism, we evaluated whether the administration of capybara oil (CO) would have the ability to reverse or attenuate the alterations in the metabolism of carbohydrates and lipids and the pancreatic remodeling imposed by the consumption of a high-fat diet in C57BL/6 mice. Thirty-two, 3-month old male C57BL/6 mice received standard chow (SC, 10% of energy as lipids, n=16) or HFty diet (HF, 60% of energy as lipids, n=16). At week 12, the animals fed the High-Fat (HF) diet were then randomly assigned to one of the following groups: Standard chow (C group); Standard Chow + Capybara Oil (C +CO group); High-Fat diet (HF group); High-Fat diet + Capybara Oil (HF + CO group). Body mass (BM), plasmatic parameters, pancreas and adipose tissue structures were analyzed. All animals fed the high-fat diet gained more weight than animals in the SC group. Excess weight was not reversed by CO. No significant differences were observed between groups and their respective controls in carbohydrate metabolism. An increase in pancreatic islet diameter and immunostaining for insulin was observed in the HF group, while a reduction of this parameters was revealed in the CO-treated group. The HF diet fed groups demonstrated that pancreatic steatosis was significantly higher than the SC group. When comparing the HF group treated with CO against the untreated HF group, the group treated with capybara oil showed a reduction in pancreatic steatosis. CO promoted improvement in pancreatic remodeling, as it resulted in the normalization of biometric, morphological and ultrastructural parameters of the pancreas of animals submitted to a HF.

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