WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

ISSN 2457-0400

Impact Factor  :  5.464

News & Updation

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in WJAHR coming Issue.

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • 6th International Conference on Human and Soci

    Venue:FCT Education Resource Center, Abuja- Nigeria                                        September 22-24, 2019

  • WJAHR New Impact Factor

    Its our Pleasure to Inform you that WJAHR Impact Factor has been increased from  4.897 to 5.464 due to high quality Publication at International Level

  • .

    6th INTERNATIONAL CONFERENCE ON EDUCATIONAL TECHNOLOGY AND CURRICULUM STUDIES(ICETC2019) 

     

    Venue: FCT Education Resource Center, Abuja-Nigeria

    September 22-24, 2019

  • WJAHR: AUGUST ISSUE PUBLISHED

    AUGUST 2022 Issue has been successfully launched on 1 August 2022.

  • New Issue Published

    Its Our pleasure to inform you that, WJAHR 1 August Issue has been Published, Kindly check it on https://www.wjahr.com/home/current_issues

Best Paper Awards

World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.

Best Article of current issue

Download Article : Click here

Indexing

Abstract

DESIGN AND CHARACTERIZATION OF BUCCOADHESIVE TABLETS OF VERAPAMIL HYDROCHLORIDE

*Bharjeet Thokchom, Ayush Garg, Jayesh Dwivedi and Dileep Kumar

ABSTRACT

The aim of the study is to design and characterization of buccoadhesive tablet of verapamil hydrochloride Verapamil Hydrochloride is a calcium channel blocker and class IV antiarrhythmic agent used in the supraventricular arrhythmias, and in the management of angina pectoris, hypertension and myocardial infarction. Buccal tablets of Verapamil Hydrochloride were formulated using four mucoadhesive polymers namely, Carbopol 934 P, HPMC K4M, Hydroxy ethyl cellulose and Sodium corboxymethylcellulose carried out studies for weight variation, thickness, hardness, content uniformity, swelling index, Bioadhesive strength and in vitro drug release. The cumulative % of drug release of formulation F6 was 97.01. In-vitro releases of F6 was found to be diffusion controlled and followed zero order kinetics. The stability studies of formulation F6 showed that there was no significant change in adhesive strength, in-vitro release when stored at room temperature and 40oC, for a period of 30 days. The formulation F6 containing 45 mg Carbopol 934 P and 95 mg Hydroxyethyl cellulose are considered as a optimized formulations with respect to bioadhesive strength (26.5gm), and in vitro drug release (97.01%). The drug release pattern of this formulation was found to be non-fickian and approaching zero order kinetics. Stability study of the optimized formulation was carried out and there was no significant change with respect to adhesive strength and in vitro drug release.

[Full Text Article]