WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Akasha A. S.*, Sharaf Eldeen R. I., Afaq A. and Khadija A.

ABSTRACT

Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multisystem inclusion and is related with significant morbidity and mortality. Hematologic manifestation abnormalities are common in systemic lupus erythematosus (SLE), both at the time of diagnosis and all through the illness. The major hematologic appearances of SLE incorporate anemia, leukopenia, thrombocytopenia, and increased ability for thrombosis. This study was conducted to evaluate the hematological parameters (CBC) changes of SLE and to investigate the clinical significance of D-dimer values in systemic lupus erythematosus (SLE) patients in predicting thrombosis among Sudanese patients in Khartoum state. Methodology: Cross sectional case-control study done during the period of May 2020 to August 2021 in Alrayan Specilaized Center and Omdurman military hospital in Khartoum state to evaluate the haematological and coagulation changes among Sudanese patients with systemic lupus erythromatosus. Sixty (60) SLE Patients and 40 apparently healthy individual as control), their age ranged from (15-55) years. Results: In systemic lupus erythematosus (SLE) there are significant differences in the mean of RBCs, WBCs, neutrophil, Lymphocyte, platelets count, and D-dimer between the SLE patients group and normal control group (P-value 0.003,

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