WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Lianita Primi Octaviana*, Intiyaswati, Sekar Handayani, Kusworini, Eviana Norahmawati, Setyawati Soeharto, Retty Ratnawati, Husnul Khotimah, Arsana

ABSTRACT

The free radicals contained in cigarette smoke can improve oxidative stress. The state of oxidative stress results in decreased levels of 17?-estradiol. Oxidative stress is also able to reduce on the work of ovarian folliculogenesis Rattus norvegicus Exposured by cigarette smoke. Importance sought natural alternatives that are rich in antioxidants and anti-inflammatory. This study aims to prove the influence provision of Ethanol Extract Red Beet (Beta vulgaris L.) To increased Levels17?-estradiol and folliculogenesis Sample use female rats exposed to cigarette smoke 2 sticks per day for 56 days. Red beet (Beta vulgaris L.) containing betalain potential as an antioxidant and anti-inflammatory. Experimental studies using post-test only control group design, Sample use female rats (Rattus novergicus) as many as 25 animals. Rats were divided into 5 groups that group control negative (no treatment), control group positive (exposed to cigarette smoke), the group P1 (exposed to cigarette smoke and were given ethanol extract of red beet dose of group 1 (exposed to cigarette smoke and red beet extract ethanol dose of 125 mg.Kg.WB-1/day), group P2 (exposed to cigarette smoke and red beet extract ethanol dose of 250 mg.Kg.WB-1/day) and group P3 (exposed to cigarette smoke and red beet extract ethanol dose of 500 mg.Kg.WB-1/day). The results showed that red beet extract Increased level of 17?-estradiol and folliculogenesis with p-value = 0.000 <?. It can be concluded that the extract of ethanol red beet (Beta vulgaris L.) can increase the levels of 17?- estradiol and folliculogenesis Sample use female Rattus norvegicus to cigarette smoke exposed.