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PHARMACOLOGICAL SCREENING OF ANTI-ULCER POTENTIAL OF HYDROALCOHOLIC LEAVES EXTRACT (HLE) OF AZADIRACHTA INDICA
*Vipin Sahu, Yusuf Siddiqui and Zeashan Hussain
Stomach ulcer is also termed as gastric ulcer, are lesions that form on the stomach lining. In total, 23 patients who were diagnosed with UC, resulting in a 44.3% prevalence rate. This research focuses on pharmacological screening of anti-ulcer potential of hydroalcoholic leaves extract of Azadirachta indica in albino rats by following standard protocols. Leaves of A. indica were obtained from the Lucknow region. It will be identified and authenticated by a botanist. The leaves are washed making dust-free and dried at room temperature or shade. The dried leaves are rendered into coarse powders and then finally into fine ones. The powder is weighed and soaked into hydroalcoholic solution- Ethanol + distilled water (1:1) for fifteen days with gradual stirrings. Rats were divided into 4 groups. Pylorus ligation method was used to induce ulcer and different parameters were evaluated such as pH, volume of gastric content, UI and % Ulcer inhibition with histopathological studies. A. indica significantly exhibited anti-ulcer activity in all the models. In conclusion, A. indica has significant anti-ulcer potential at both the doses used 200mg/kg and 400mg/kg. It may prevent ulcer formation by the same action as ranitidine does. This study suggests to isolate and develop the suitable dosage form of concerning chemical constituents for the activity.[Full Text Article]