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THE RELATIONSHIP BETWEEN ELEVATED SERUM GAMMA-GLUTAMYL TRANSFERASE (GGT) AND BREAST CANCER INCIDENCE
Dr. Nardeen Ibrahim*, Nader Abedallah and Faisal Radwan
Background: Breast cancer is the most common malignancy in females, and the second most common cause of cancer-related death in women in developed countries, but it is the first cause of cancer-related death in women in developing countries. For the early detection of breast cancer, a number of biochemical markers have been studied to evaluate the malignancy. Aim: The present study aimed to evaluate the gamma-glutamyl transferase (GGT) levels in the circulation of patients of breast cancer and comparing with controls. Materials and Methods: This was a prospective case – control study included 031 patients with stage (I-III) breast cancer and 100female controls matched for age at Tishreen University Hospital, Lattakia during the period between 30/01/ 2020 –30/01/ 2021. The serum GGT was estimated. The statistical analysis was done by using SPSS software. The results were expressed as Mean ± SD. The student’s paired 't'-test and ANOVA were carried out for comparison of data & p-value <0.005 was considered statistically significant. Results: The mean serum GGT level in breast cancer patients was significantly (p<0.001) increased as compared to controls, and we also found that the levels was gradually increased with advancing stages and grades of breast cancer. Serum GGT level in post-menopausal breast cancer patients was significantly increased as compared to premenopausal breast cancer patients. Conclusion: Serum GGT levelis reliable and inexpensive promising enzyme marker with prognostic and diagnostic importance in breast cancer patients.[Full Text Article]