WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

ISSN 2457-0400

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Indexing

Abstract

HYPOGLYCEMIC EFFECT OF ‘PORANG’ FLOUR (Amorphophallusmuellery Blume) ON HYPERGLYCEMIC RATS AND IN SILICO PHARMACODYNAMICS ANALYSIS

Novita Dewi*, Karyono Mintaroem, Moch Muljohadi Ali, Hidayat Suyuti, Hani Susianti

ABSTRACT

Background: An acute hyperglycemia is a life-threatening emergency, occurring in patients with plasma glucose more than 600 mg/dL. Hyperglycemia could be managed by lowering blood plasma glucose.Porang bulb (AmorphophallusmuelleriBlume) is expected to have a hypoglycemic effect on hyperglycemic rats, and there is no in-silico mechanism explaining the process. This study aimed to investigate the hypoglycemic effect of Porang flour (AmorphophallusmuelleriBlume) in hyperglycemic rats and its in-silico pharmacodynamics analysis. Methods: The study was performed on25 hyperglycemic rats with the pre-post test only control group design. Rats was divided equally in five groups, namely normal group (K), hyperglycemic group (K+), Porang flour treatment group with dose 100 mg/kgBW (P1), Porang flour treatment group with dose 200 mg/kgBW (P2), and Porang flour treatment group with dose 400 mg/kgBW (P3).Induction of hyperglycemia was performed with 60% high fructose diet and intraperitoneal STZ injection with dose 25 mg and 30 mg. We measured pre test blood glucose. The insilico instruments used werepubchem and molinspiration, icd lab, string and stitch, pymol, and pyryx.The data were analyzed usingt test (p<0.05). Results: results showed the treatment of porang meal contributes significantly to the average GDP. There are two mechanism action of glucomannan (non-receptor) and action of Metabolite glucomannan (acetate, butyrate, propionate) (receptor). Conclusions: These findings different results effects of porang flour in hyperglycemic rats and pharmacodynamic analysis in insilico metabolite glucomannan had an unequal mechanism of action with hypoglycemic agent metformin, possibly another more influential mechanism.

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