WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Karunakar Hegde*, Muhamed Suhail, Anvitha D. K.

ABSTRACT

The anti-diabetic potential of Momordica charantia Linn leaves extract was performed against Alloxan and Streptozotocin induced diabetic in rats. Two doses of hydroalcoholic extract of M. charantia leaves 200 mg/kg, p.o and 400 mg/kg, p.o, body weight, and standard drug glibenclamide were used against diabetic activity and parameters estimated includes estimation of biochemical parameter (serum cholesterol, TG, HDL, LDL) macroscopic evaluation and microscopic evaluation (histopathology). Both the lower (200mg/kg, p.o) and higher dose (400mg/kg, p.o) of M charantia leaves extract showed dose dependent significant decrease in blood glucose level and biochemical parameters such as cholesterol, triglyceride, LDL, and HDL level were increased when compared with diabetic control of both the models. Histopathology of pancreas showed regeneration of ?-cells in extract treated diabetic rats. The result obtained was comparable with that of the standard drug Glibenclamide. The finding of the present study provides the evidence that, hydroalcoholic extract of M. charantia Linn leaves may be beneficial against Alloxan and Streptozotocin induced diabetes mellitus.