WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Jyoti Singh*, Amit Sirdesai and Prasun Bandyopadhyay

ABSTRACT

The oral cavity is under continues exposure to hot & cold drinks & junk foods, substances such as alcohol, tobacco products and nicotine etc. which contribute towards production of free radicals. Presence of bacteria and other disease-causing agents further aggravates the oxidative damage.[1] Oxidative stress in oral disease is related to other systemic diseases in the body such as periodontitis, cardiovascular, pancreatic, gastric, and liver diseases.[2] There is significant attention of researchers to the potential benefit from the use of antioxidants in the field of dental medicine. In this study antioxidant and antiaging potential of TIs (Test Items) were investigated using two cell system: WI-38 (Human lung fibroblast) & HGF (Human Gingival fibroblast). Since the oral mucosa is constituted of fibroblasts, these cell types are highly relevant for testing oral care products. Two marketed ayurvedic dentifrices (Dabur Dant Rakshak Paste & Dabur Red Paste) were selected for the study based on presence of antioxidant & antiaging ayurvedic ingredients in the formulation. e.g., Cinnamonum zeylanicum & Syzygium aromaticum are proven antioxidant ayurvedic herbs. Piper longum,[3] Salvadora persica,[4] & Glycyrrhiza glabra [5] are ayurvedic rasayanas (Rejuvenators) which commonly used for antiaging & cell rejuvenation benefits in ayurveda. Dabur Red Paste, Dabur Dant Rakshak Paste demonstrated antioxidant potential via cytoprotection and inhibition of reactive oxygen species (ROS) generation in both WI-38 and HGF cells system. In addition, both the ayurvedic toothpaste exhibited wound healing potential which confirms their antiaging properties when compared against placebo.