WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
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  • Scientific Journal Impact Factor (SJIF)
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  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
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Abstract

CARVEDILOL COMPARED WITH METOPROLOL SUCCINATE IN THE TREATMENT AND PROGNOSIS OF PATIENTS WITH STABLE CHRONIC HEART FAILURE

Premshanker Singh*, Vikram Singh, Mridu Singh, D. P. Singh, PK. Singh

ABSTRACT

?-Blockers exert a prognostic benefit in the treatment of chronic heart failure. Their pharmacological properties vary. The only substantial comparative trial to date—the Carvedilol or Metoprolol European Trial—has compared carvedilol with short-acting metoprolol tartrate at different dose equivalents. We therefore addressed the relative efficacy of equal doses of carvedilol and metoprolol succinate on survival in single center tertiary care hospital of Dr RML Institute of Medical Sciences, Lucknow(DR RML IMS LKO) India. Two thousand and eight hundred patients with stable systolic chronic heart failure who were using either carvedilol or metoprolol succinate were identified in Medical OPD(MOPD) of Dr RML Institute of Medical Sciences, Lucknow(DR RML IMS LKO), India Patients were individually matched on both the dose equivalents and the respective propensity scores for ?-blocker treatment. During a follow-up for 17 670 patient-years, it was found that 304 (27.2%) patients died in the carvedilol group and 1066 (36.8%) in the metoprolol group. In a univariable analysis of the general sample, metoprolol therapy was associated with higher mortality compared with carvedilol therapy (hazard ratio, 1.49; 95% confidence interval, 1.31–1.69; P

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