WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Premshanker Singh*, Ajay Misra, Devendra Kumar, Manoj Kumar and Granth Kumar

ABSTRACT

Previous meta-analyses have suggested that diabetes confers a greater excess risk of coronary heart disease(CHD), stroke, vascular dementia and heart failure in women compared to men. While the underlying mechanism that explains such greater excess risk is unknown. In the current analysis, we hypothesized that we would find a similar sex difference in the relationship between diabetes and peripheral arterial disease (PAD).We conducted a prospective study to find out correlation of Type2-DM(T2-DM)and Peripheral vascular disease(PVD)and higher incident PVD in women than men We conducted present study at tertiary care hospital;UP University of Medical Sciences(UPUMS), India. All participants were enrolled in Medical OPD(MOPD)of UPUMS,India and study was carried out prospectively at this single centred tertiary care hospital We recruited and did periodic assessment and review for 09 years wef Apr2008 to2017 The relative risk (RR), and its variability, for incident PAD associated with diabetes in both sexes was evaluated. We excluded those participants who were not adjusted at least for age and in which participants had pre-existing PAD. Random-effects Prospective analyses with inverse variance weighting were used to obtain summary sex-specific RRs and the women: men ratio of RRs for PAD. The Newcastle–Ottawa scale was used to assess study quality 20712participants (49.8% women), were included in this study. The relative risk for incident PAD associated with diabetes compared with no diabetes was 1.96 (95% CI 1.29–2.63) in women and 1.84 (95% CI 1.29–2.86) in men, after adjusting for potential confounders. The multiple-adjusted RR ratio was 1.05 (95% CI 0.90–1.22), with virtually no heterogeneity between studies (I2 = 0%). studies scored 6–8, on the Newcastle–Ottawa scale of 0–9, indicating good quality.there was no sex-specific relative risk Consistent with other studies, we found evidence that diabetes is an independent risk factor for PAD. However, in contrast to similar studies of other types of cardiovascular disease, we did not find evidence that diabetes confers a greater excess risk in women compared to men for PAD. More research is needed to explain this sex differential between PAD and other forms of CVD, in the sequelae of diabetes. In addition, we found that very few studies reported the sex-specific relative risk for the association between diabetes and PAD, adding to existing evidence for the need for improved reporting of sex-disaggregated results in cardiovascular disease research.

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