WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Premshanker Singh*, Devendra Kumar, Manoj Kumar, Granth Kumar and P.K. Singh

ABSTRACT

Prehypertension frequently progresses to hypertension, a condition associated with high morbidity and mortality from cardiovascular diseases and stroke. However, the risk factors for developing hypertension from prehypertension remain poorly understood. We conducted a retrospective study using the data from 2008 to 2017 prehypertensive Indian adults (52.1±11.0 years, 1040 men) found to be prehypertensive in 2008 and reexamined in 2017. We calculated the cumulative incidences of hypertension over 09years, examined risk factors and calculated odds ratios (ORs) for developing hypertension after adjustments for age, sex, body mass index, smoking and drinking habits, baseline systolic and diastolic blood pressure, pulse rate, diabetes mellitus, dyslipidemia, chronic kidney disease, and serum uric acid levels. The additional analysis evaluated whether serum uric acid (hyperuricemia) constituted an independent risk factor for developing hypertension. The cumulative incidence of hypertension from prehypertension over 9 years was 25.3%. There were no significant differences between women and men (24.4% versus 26.0%; P=0.28). The cumulative incidence of hypertension in subjects with hyperuricemia (n=363) was significantly higher than those without hyperuricemia (n=1279; 30.7% versus 24.0%; P

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