WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Indexing

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  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
  • IFSIJ Measure of Journal Quality
  • Scientific Journal Impact Factor (SJIF)
  • International Scientific Indexing, UAE (ISI) (Under Process)
  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
  • Scholar Article Journal Index (SAJI)
  • International Scientific Indexing ( ISI )
  • Academia
  • Scope Database

Abstract

ROLE OF TNF-ALPHA, NF-ΚB AND SOME SELECTED INTERLEUKINS IN TRAMADOL RELATED MULTI-ORGANS DAMAGE IN RATS

*Abdulghaffar Asaad Abdulameer, Ahmed Saadi Khaleefah and Enas Amoori Hadi

ABSTRACT

Introduction: Tramadol, an opioid medication used to treat moderate-moderately severe pain. The most common adverse effects of tramadol include nausea, dizziness, drowsiness and headache. The aim of study to investigate the effects of toxic doses of tramadol on liver, heart and brain of rats by utilizing diverse duration of exposure and to assess the concentration of tramadol in each of the above mentioned organs. Method: Thirty-five (35) adult Wistar Albino male rats; their age range (3-5) Months, weighing 200-250g were utilized in this study. They were obtained from the Animal House of the College of Pharmacy/Baghdad University. The animals were randomly allocated into five groups (7 animals each) as follows: (14 rats) and sub-divided into two sub-divisions: A- Rats IP injected with (0.5ml /250gm body weight) normal saline administered. B- Rats received twice-daily toxic dose (54mg/kg) tramadol for 8 days. Results: rats IP injected twice daily there were non-significant differences (P>0.05) in serum levels of -tumour necrosis factor-alpha, -nuclear factor kappa-light-chain-enhancer of activated B cells, -interleukin-10, -interleukin-1beta, -creatine kinase-MB, -aspartate aminotransferase, -alkaline phosphatase, and -aldehyde dehydrogenase, while, serum activity level of alanine aminotransferase enzyme activity was significantly decreased (P

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