WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Indexing

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  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
  • IFSIJ Measure of Journal Quality
  • Scientific Journal Impact Factor (SJIF)
  • International Scientific Indexing, UAE (ISI) (Under Process)
  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
  • Scholar Article Journal Index (SAJI)
  • International Scientific Indexing ( ISI )
  • Academia
  • Scope Database

Abstract

SYSTEMIC ALK-NEGATIVE ANAPLASTIC LARGE CELL LYMPHOMA: A CASE REPORT OF AN ASYMPTOMATIC PATIENT FROM SYRIA

Lujain Hamdan*, Souliman Diab, Zuheir Al-Shehabi and Michael Georgeos

ABSTRACT

Anaplastic large cell lymphomas (ALCLs) are uncommon malignancies; they include a group of CD30-positive Non-Hodgkin T-cell lymphomas that share similar morphologic and immunophenotypic features. The World Health Organization identifies 3 entities: primary cutaneous ALCL, anaplastic lymphoma kinase (ALK)-positive ALCL, and ALK-negative ALCL. ALK-negative ALCL is known for its aggressive behaviour and poor prognosis. It usually affects males at a median age of 55-60 years old. The majority of patients are presented with B symptoms and stage III–IV of the disease. Medical literature has reported very few cases of systemic ALK-negative ALCL. Here we demonstrate a unique case of a 47-year-old male, with no systemic symptoms, diagnosed with a stage IV, CD30+, ALK-negative ALCL presented with several tender, enlarged, inguinal lymph nodes and extranodal involvement in the skin, lung, liver and the bone marrow.

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