WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Premshanker Singh*, Ritu Karoli and Shobhit Shakya

ABSTRACT

Depression is a mood disorder which is characterized by helplessness, hopelessness and worthlessness According to World Health Organization (WHO), more than 4 percent of the world’s population deals with depression. Vitamin D plays an important role in the transcriptional activation of serotonin (an important neurotransmitter) which influences various brain functions including mood, sleep and appetite. As a an important neurosteroid hormone, vitamin D plays as an important role in depression. Vitamin D insufficiency may result in depression. It has been observed in several studies that patients with depression had low vitamin D. The study was carried to find out correlation between vitamin D and depression.100 cases of depression and 100 age and gender matched controls were studied over a period of 3 years in Dept of Medicine, Dr RML Institute of Medical Sciences Lucknow, UP, India-226010. Serum Vitamin D was found to be statistically significant and higher in the control group as compared to patients having depression (p=0.033). In this study it was found that depression shows a correlation with serum vitamin D level, indicating the intricate mechanism of vitamin D deficiency and depression.