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World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.
Best Article of current issue
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Abstract
CONTROLLING COVID-19 PANDEMIC WITH CHOLECALCIFEROL
Sunil J. Wimalawansa* MD, Ph.D, MBA, DSc
ABSTRACT
The elderly and those with underlying chronic pulmonary, cardiovascular, metabolic, and renal diseases are at a higher risk for experiencing COVID-19 infection and more prone to serious clinical complications, such as cytokine storm and acute respiratory distress syndrome, leading to death. In addition to pulmonary cells, COVID-19 also impairs endothelial cells and could initiate intravascular haemolysis and microvascular thrombosis, and consequent pulmonary microembolization, which leads to multi-organ failure and death. VitaminD adequacy however, can minimize the mentioned harmful outcomes. Sufficient exposure to ultraviolet B rays from sunlight and/or adequate doses of vitamin D supplements enhances the immune system. In vitro and in vivo data suggest that having adequate vitamin D, increased expression of anti-inflammatory, antioxidant, and anti-microbial related genes. These, suppress excessive inflammation and oxidative processes, and therefore, minimize the symptomatic COVID-19 infections, associated complications, and enable rapid recovery. Whereas, weaker immune systems are primarily responsible for complications and deaths from COVID-19. Administration of higher doses of vitamin D can rapidly boost the immunesystem. It is the most cost-effective way to keep the immune system at high alert and prevent complications and deaths from COVID-19. Therefore, one should proactively consider using a combination of safe sun exposure and oral vitamin Dsupplements to prevent and manage COVID-19. In addition, ivermectin and hydroxychloroquine could also use cost-effectively in those who had been expos-ed to a person with COVID-19, immediately after become PCR positive, and in early stage of the disease.
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